Boxed warnings alert doctors and patients about drug effects that may be dangerous. Injectafer is indicated to treat iron deficiency anemia (IDA) in adults who meet one of the following criteria: Injectafer is administered intravenously, either by intravenous (IV) infusion or as an undiluted, slow IV push. Some drugs may have another patient information leaflet. Venofer is given as an infusion into a vein. But you kidneys need iron in order to make EPO. 1 0 obj The study also didnt show if one treatment was worse than the other. A healthcare provider will give you this injection. Additional studies are ongoing to see if Injectafer is a safe and effective treatment option for these conditions. Other drugs are available that can treat iron deficiency anemia (IDA). Symptoms include shock, dangerously low blood pressure, loss of consciousness, and/or collapse. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. However, side effects at the 150 mg dose may indicate that you might not . Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: These are not all of the side effects that may occur. Side effects like nausea and low blood pressure are common with most iron infusions. As with all medications, the cost of Injectafer can vary. (Hemoglobin is a protein thats found inside your red blood cells.). Details. Symptoms of overdosage include drowsiness, mental confusion, dizziness, diarrhea and vomiting etc. Headache. Then the study was split into the following two groups, which are discussed below. The next time the doctor prescribesprescription medication, ask aboutcommonside effectsand if they are known to last a short or longtime. All of the people took iron by mouth for 2 weeks. On day three I had a headache and felt heavy/exhausted, which lasted a few days. Last reviewed . Remember that it is best to get your vitamins and minerals from food whenever possible. 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. And this can affect how well those parts of your body are able to work. Details. However, since peoples bodies react so differently to drugs, they often have to change their stance on certain drugs. The iron released by this drug does pass into human breast milk. It is given into a vein for a period of time. endobj It can be given as a slow injection over 2 to 5 minutes or as an infusion. But for most people whove developed hypophosphatemia with Injectafer, the condition resolved within 3 months. Many people using this medication do not have serious side effects. Injectafer contains the active drug ferric carboxymaltose, while Venofer contains the active drug iron sucrose. For people with certain medical implants, such as pacemakers, an MRI may pose an . These lists contain up to 10 of the most common mild side effects that can occur with Injectafer, with Feraheme, or with both drugs (when taken individually). A delayed reaction can occur in two different ways: It can happen hours or days after you receive a drug, or it can happen after a second (or later) dose of a drug. If this happens to you, your doctor may recommend that you receive another treatment course of Injectafer. All rights reserved. And if you dont have an allergic reaction to your first dose of a drug, its typically safe to assume you wont have an allergic reaction to doses that follow. There have also been reports of serious allergic reactions to Venofer. People who weigh 110 pounds (about 50 kilograms) or more will receive two separate Injectafer doses of 750 milligrams each. TheNational Instituteof Health (NIH) and the U.S. Food andDrug Administration(FDA) monitor theside effectsof new and approved medications to ensure safety. For reasons we dont fully understand, some peoples immune system gets over-activated when the drug enters their body. They can recommend if this is safe for you to do. Effectiveness of Injectafer compared with iron thats taken by mouth. These side effects may include constipation and diarrhea. But even if youre not at risk for the condition, your doctor may still monitor your phosphorus levels. This is why the FDA hasa programcalledMedWatchthat encourages Americans to report adversereactions. This is why family members often have the same issues with drugs as others in theirfamily. fever. After getting each dose of Injectafer, your healthcare professional will monitor you for at least 30 minutes. Check with your pharmacist if you have questions about the best way to throw out drugs. You should always consult your doctor or another healthcare professional before taking any medication. This document does not contain all possible drug interactions. Learn more about the types of tests and treatment. Theseeffects of medicine on thebodycan also lead to medication non-compliance and worsening of themedical conditionthey are meant to treat. Why is the range so wide? Some people may also experience skin irritation from the adhesive tape and other medical equipment used during the procedure. * This is a partial list of mild side effects from Injectafer. For people weighing less than 50 kg, administer Injectafer in two doses of 15 mg/kg of body weight, at least 7 days apart. If you are allergic to Venofer; any part of this medicine; or any other drugs, foods, or substances. You should not be treated with this medicine if you have ever had an allergic reaction to an iron injection. In fact, Injectafer is meant for some people whose anemia didnt improve with iron pills or for people who had side effects from iron pills. Iron is also necessary for your bone marrow to build healthy new red blood cells and provide oxygen to your . Do not use Injectafer in people with a history of hypersensitivity reactions to Injectafer or any components of the drug product. All patients receiving Venofer require periodic blood tests to monitor the amount of iron in the blood. 3 0 obj Check with your pharmacist. Iron sucrose can also be mixed in a. Usually, when drugs may cause an immune system reaction like this, its a concern with your first dose of the drug. Phosphorus also helps your nerves function properly. Its FDA-approved to treat iron deficiency anemia (IDA) in adults. generalized weakness. For people weighing 50 kg (about 110 lb) or more, administer Injectafer in two doses of 750 mg, at least 7 days apart. Have blood work checked as you have been told by the doctor. Potentialside effectsthat are usually mild may include, but are not limitedto: Theseside effectsmay not impact life too much and may only be temporary. Injectafer infusions are given over a period of at least 15 minutes. What is Venofer? (A class of medications describes a group of drugs that work in the same way.). After 5 weeks of treatment: This study didnt determine if either drug was better than the other. Drug interactions may change how your medications work or increase your risk for serious side effects. Its caused by your body not having enough iron, which is needed to make hemoglobin. muscle pain. I had Venofer infusions, 2 rounds now in the span of three years. How long it takes for the bodyto break down the meds matters and some peoples bodies simply take longer than others. These include: Note: For more information about the potential negative effects of Injectafer, see the Injectafer side effects section above. How is Venofer (iron sucrose) given? Your doctor will be able to see how Venofer is working by reviewing your blood tests. %PDF-1.3 It depends. Common side effects of Venofer include: muscle cramps, nausea, vomiting, stomach pain, strange taste in the mouth or decreased sense of taste, diarrhea, constipation, headache, cough, sore throat, sinus pain, congestion, back pain, joint pain, dizziness, weakness, tired feeling, anxiety, ear pain, swelling of the arms/legs, or In clinical trials, serious allergic reactions occurred in 0.1% to 1.5% of people taking Injectafer. What Is the Cost of Whole Genome Sequencing (WGS)? Brand-name medications usually cost more than generics. This is not a complete list of side effects and others may occur. I got Venofer twice in the last few years and now my iron deficiency is worse than ever, first time my hemoglobin is down to 11,2. Can diet help improve depression symptoms? Do not share your drugs with others and do not take anyone else's drugs. Pain in your limbs. Source: Wolters Kluwer Health. Venofer is not for treating other forms of anemia not caused by iron deficiency. The way thatprescription drugsand evenover-the-countermedications interact with a body is influenced by manyfactors. People in the study received treatment with either Injectafer or Venofer. Examples of other drugs that may be used to treat IDA include: Your doctor will recommend the drug thats right for you depending on the severity of your anemia and any other medical conditions you may have. Iron sucrose injection has a molecular weight of approximately 34,000 - 60,000 daltons and a proposed structural formula: Last updated on Feb 20, 2023. Consult your pharmacist or local waste disposal company. On the other hand, some people may have a poor appetite that goes away when their anemia is treated. But its not known whether this poses any risk to a child whos breastfed. Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. Injectafer may not be right for you if you have certain medical conditions or other factors affecting your health. Learn more about these, as well as the symptoms, diagnosis, and treatments. These lists contain examples of serious side effects that can occur with Injectafer, with Feraheme, or with both drugs (when taken individually). Venofer may cause serious side effects including: problems with your dialysis vein access point, chest pain, severe headache, blurred vision, pounding in your neck or ears, lightheadedness, pain or swelling, bloating, nausea, vomiting, loss of appetite, diarrhea, and fever Get medical help right away, if you have any of the symptoms listed above. If this happens, you may need to get another treatment course of Injectafer, if your doctor recommends it for you. For more information about taking Injectafer during pregnancy, see the section Injectafer and pregnancy above. reese0809 1 yr. ago. This test measures the amount of hemoglobin in your blood. If you have questions about using Injectafer in a child, talk with your doctor. (IV iron is absorbed by the body more rapidly than oral iron.) xmq92\Kz!yIP}2~(?c/JUCK2~o_N=>K$o/_7'Z+nRkKM^y{u|ZFh$v}]O~vfo=.GowGFodVj-[-~x]Kg~9H'%h={OX/#S|Mc~|]_2nv`wwotn/+$G[{hGrP}sbZG-RGf#l~~l|Qnccml_iPy]G\17c,yPF[28z&I'+B(?rrvi,G?}/;'?;pm>?.i42ONmk~ai_u0z9o_? Both of theseside effectscould worsen depression and lead tolife-threateningconsequences. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Side effects: DayQuil can cause side effects such as drowsiness, dizziness, nausea, vomiting, and stomach upset. But its only approved for use in people with CKD who may or may not need dialysis. Foods rich in iron include meats (especially liver), eggs, raisins, figs, broccoli, brussels sprouts, beans, lentils, and iron-fortified or enriched cereals. Side effectsare uncomfortable reactions to medications or drugs. If youre interested in finding an alternative to Injectafer, talk with your doctor. dizziness. Your doctor will go over your
But you likely wont feel the drug working inside of you. With IV infusion, the drug is given as a slow drip into your vein over a period of time. Suffering from somemedical conditionsput people at risk fordrugside effectsof medications for other health concerns. Keep all regular medical and laboratory appointments. In the second group, some people switched from taking iron by mouth to taking Injectafer. The following information is provided for clinicians and other healthcare professionals. Reblozyl is a brand-name prescription medication used to treat anemia in certain blood disorders. Seriousside effectsshould be reported to a physician and/orPharmDfor medical advice. Dizziness. With this condition, you also have a low hemoglobin level. Ask your doctor or healthcare provider if Venofer is the right choice for you. Your body then uses the iron from Injectafer to make hemoglobin and new RBCs. These lists contain examples of serious side effects that can occur with Injectafer, with Venofer, or with both drugs (when taken individually). Reactions around the injection/infusion site, such as pain, irritation, itching, bleeding, or discoloration after leakage of injection into the skin. Selected from data included with permission and copyrighted by First Databank, Inc. This could happen because Injectafer helps increase their hemoglobin levels, but it doesnt address the underlying cause of their anemia. Tell your doctor about the allergy and what signs you had. In one study, people were given either Injectafer or an iron replacement drug called Venofer. You should not receive Venofer if you have known allergies to iron sucrose. This may be helped by giving the medication more slowly or at a lower dose. Orofer S 100 Injection 1 Injection in 1 Packet 286 301 5% off. Diarrhea. fever. Any long-term side effects/dangers from iron infusions? Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Venofer only for the indication prescribed. If youre wondering how longside effectslast, youll be happy to know they can last just a few hours. Mental healthdisorders like depression may requireantidepressantsto treat. Health careproviderscan provide information on how longside effectslast by checking amedication guide. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Injectafer can cause mild or serious side effects. You may report side effects to the FDA at 1-800-332-1088. Then your body uses that iron to make hemoglobin and RBCs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Properly discard this product when it is expired or no longer needed. Daiichi Sankyo, Inc., the manufacturer of Injectafer, offers a program called injectconnect, which may help lower the cost of the drug. Examples of thisinclude: Not allside effectslast forever. }|54U|O~?|_v;f\o^(W+/-|^)O65_)rd
sm }[x[)y.z Wz?9_jV0ub,`g`s?oXOSp/Kgw$b!Vb$;IvBVR9n|\0ln=;/=,mgw@do,[";/8nJL{n}Bb-|^6[~>a_1H'^M:^vv=iM+x|+Y treatment schedule in further detail. Understanding what thoseside effectsare can lead to a strategy to prevent them. Do not double the dose to catch up. Iron infusions are given directly into a vein. Renal elimination is negligible. Always review your medical history with the treatingphysician. Youll receive doses of either drug by a healthcare professional at a medical facility. What to Expect When You Get Your Whole Genome Sequenced, DNA Data Can Help You Understand Ehlers-Danlos Syndrome (EDS). One study of just under 5000 HRT users found that 43% were affected. Injectafer and Feraheme are both brand-name drugs. If you have diarrhea while youre taking Injectafer, call your doctor. MNT is the registered trade mark of Healthline Media. This gives a total cumulative dose of 1,500 mg of Injectafer. Notify your healthcare provider of any irritation at the injection site. Very bad and sometimes deadly allergic side effects have rarely happened. Venofer may cause significant hypotension (decreased blood pressure). For this purpose, Injectafer is approved for use in adults who either: Venofer is also approved to treat IDA. Side effects are uncomfortable reactions to medications or drugs. This treatment course is split into two doses of the drug, which are given at least 7 days apart. Some people are simply allergic to an active ingredient in the medication, so the body responds undesirably. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. <> (See also Notes section.). Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Discuss the risks and benefits with your doctor. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. Once inside your body, ferric carboxymaltose releases iron into your system. If you have questions about the blood tests youll need to have done to monitor your anemia, talk with your doctor. Typical Injectafer doses for iron deficiency anemia (IDA) depends on your body weight. pain in the arms or legs. Taking a higher dose than needed can often lead to adverse effects. In the first group, some people continued taking iron by mouth, while other people took Injectafer. You can also write a reminder on your calendar. So the goal of anemia treatment is to increase your hemoglobin level back to a value thats within a normal range. Your doctor will do laboratory tests to monitor your response. Other drugs may interact with iron sucrose, including prescription and over-the-counter medicines, vitamins, and herbal products. <> Iron sucrose can harm an unborn baby if you have a severe reaction to this medicine during your second or third trimester. And babies born to those who took Injectafer during pregnancy didnt have any major congenital anomalies (also sometimes called birth defects). (A medication class is a group of medications that work in a similar way.). Most people will metabolize medication by half every time it circulates the body. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction. Do not flush down a toilet or pour down a drain unless you are told to do so. Injectafer isnt a medication that youll take regularly on a schedule. I hope you found answers and are feeling better now. The time it takes to infuse Venofer (iron sucrose) depends on your age, if you're on dialysis, and the type of dialysis you need. Injectafer and Venofer have different approved uses, but theyre both used to treat IDA in people with CKD. TheNational Instituteof Health (NIH) and the U.S.Food and Drug Administration(FDA) monitor the side effectsof new and approved medications to ensure safety. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. But for other people, their IDA returns after treatment with Injectafer. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. All rights reserved. Talk to your pharmacist for more details. An LSD comedown is when the mental and hallucinatory effects have worn . Since someallergic reactionscan belife-threatening, its essential to discuss any adverse events previously experienced with the prescribingphysician. What should I know regarding pregnancy, nursing and administering Venofer Vial to children or the elderly. These are not all of the side effects that may occur. Tell all of your health care providers that you take Venofer. This hormone is made by your kidneys. Notify your healthcare provider of all medical conditions and any medications, including supplements you are taking. Its not currently available in generic form. While the side effects that occur during treatment with these drugs are increasingly well-cataloged, the long-term side effects that may result from receiving these drugs are only beginning to be studied. If your symptoms or health problems do not get better or if they become worse, call your doctor. Both Injectafer and Venofer belong to a class of medications called iron replacement products. If a person does not have an allergic response or any other unanticipated reactions, a doctor will administer the remaining iron. Those going through thismedical conditionshould speak to theircare teamfor support andguidance. It's a more immediate treatment than supplements or dietary changes. Brand-name medications usually cost more than generics. Allergic reactions are most likely to occur within 30 minutes of receiving Venofer. In clinical studies, people who took Injectafer had their hemoglobin level improve as early as 35 days after receiving treatment. These changes could help improve your anemia on a long-term basis. (A generic drug is an exact copy of the active drug in a brand-name medication.) The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Its possible to get rid of or reduce the severity ofside effects. For instance, someone with lowblood pressuremay receive a medication to prevent migraines that lowersblood pressure, this may causeseriousside effects. This information should not be used to decide whether or not to take Venofer or any other medicine. Maximum concentrations of Injectafer are achieved within 15 minutes to 1.21 hours following administration. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine. Get emergency medical help if you have signs of an allergic reaction to Venofer: hives, rash, itching; feeling light-headed; difficulty breathing; swelling of your face, lips, tongue, or throat. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. 12 Medicines That Could Help, List Venofer Vial side effects by likelihood and severity. Note: The Food and Drug Administration (FDA) tracks side effects of drugs they have approved. You will need frequent medical tests to help your doctor determine how long to treat you with Venofer. Here's some detail on certain side effects this drug may cause. In clinical studies, diarrhea was reported in less than 1% of people taking Injectafer. Weight influences how fast medication breaks down in the body, so it also affects how longside effectswill last. Youll receive doses of Injectafer from a healthcare professional at a medical facility. These nutrients include iron, vitamin B12, and folate. (A generic drug is an exact copy of the active drug in a brand-name medication.). It may also cause nervousness, restlessness, and difficulty sleeping in some people. So the goal of IDA treatment with Injectafer is to bring your hemoglobin level back to a value thats within normal range. Undergoingcancer treatmentwithradiation therapyorchemotherapy drugsmay result inhair loss, which can be devastating to somepeople. An example of a drug interaction that many people are not aware of isgrapefruitjuice and statins. Call your doctor for medical advice about side effects. But the length of time that this may take varies from person to person. So the goal of IDA treatment with Injectafer is to bring your hemoglobin level back to a value thats within normal range. Drug class: Iron products. But some people have a delayed allergic reaction to certain drugs. Diarrhea is a common side effect of most iron replacement products, which is the group of drugs that Injectafer belongs to. Tell your doctor if you are taking iron supplements or other iron-based oral medications. The Role of Genetics in Multifactorial Disorders, The Power of DNA Testing and Predictive Medicine, A Guide to Genome Explorer (Free Version), Whole Genome Sequencing in As Little As Three Weeks, What Diseases Can Be Detected Through Genetic Testing, Breast Cancer Genetic Testing: Pros and Cons, At Home Genetic Testing for Breast Cancer, DNA Tests for Breast Cancer Genetic Testing, What to Do When Medicines Have Side Effects, Blood Type and COVID: Infection Risk and Severity, Where Can I Get My Blood Type Checked for Free, How to Find Biological Father Through DNA. Things to remember when you fill your prescription. Data on file, American Regent, Inc. 1. Side effects from HRT depend on a number of factors: With slow IV injection, the drug is given as a single, slow injection into your vein. People from different ethnic backgrounds process medications differently. This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. Serious side effects should be reported to a physician and/or PharmD for medical advice. ByDr. You may report side effects to Health Canada at 1-866-234-2345. No, you most likely wont take Injectafer long term. (A medication class describes a group of drugs that work in the same way.). In the study, peoples hemoglobin level was measured to check for improvement in their anemia. This allows them to manage any side effects that you may have following your dose. If you need financial support to pay for Injectafer, or if you need help understanding your insurance coverage, help is available.
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